Study: “Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures”[1]
[1] Pinar Cakmak, Lun JH, Singh A, et al. Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures. Immunity. 2025;58(11):2847-2863.e8. [doi]
Metadata: GEO (NCBI) - GSE271059[2]
IDH_status
TLS_status
Localisation
Primary_or_Recurrent
Age
Gender
Raw data: gene expression count matrix (genes × samples)
[2] GEO series GSE271059 – https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE271059
[3] Ayers et al., 2017 – https://pubmed.ncbi.nlm.nih.gov/28650338/
TLS status does not strongly separate the samples
TLS group contains highly distinct outliers
Clear and distinct separation of samples by IDH status
Outlier subsets exist